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Women's Health Research at OHSU



Current Clinical Trials and Research Study Opportunities

Our Research Team

Why Participate?

OHSU Women's Health Research Unit

503 494-3666

We are excited to announce the start of a new contraceptive study.

This one may sound familiar if you were a participant in the ring study we conducted in 2009. This new study takes the ring concept in a new direction using natural estrogen. Unlike the earlier research, this is a "proof in concept" study where we are testing the contraceptive mechanism of the new ring. This means that women enrolling in the study need to use a non-hormonal back-up method of contraception.

The National Institutes of Health and Population Council are partnering to study a new contraceptive vaginal ring containing a combination of Nestorone (NES), a kind of progestin, and estradiol (E2), a hormone that your body makes naturally.

We will be testing the new device to see if it is:

Longer-acting than NuvaRing, the only FDA-approved contraceptive vaginal ring on the market, so that a woman would have to replace it every 90 days instead of every month.

Safer and with fewer side effects than NuvaRing. Instead of containing synthetic forms of estrogen, the study ring releases estradiol, the same hormone that your body makes naturally. This estrogen is combined with a synthetic hormone Nestorone to block ovulation and prevent pregnancy. Nesterone is not approved by the FDA.

A "no-bleed" method of contraception

The purpose of this study is to learn how different dose combinations of NES/E2 effect bleeding patterns, ovulation, and other side effects, as well as to see how the body processes the drug over time.

To qualify for this study:

You must be a healthy woman between the ages of 18 39 with regular menstrual periods. You must not be using a hormonal form of birth control or a barrier method other than condoms. You do not have to be sexually active to participate in this trial, but if you are, you will be required to use condoms. This study includes up to 54 clinical visits at OHSU over an 8 month period. Participants will receive up to $3,000 in compensation.

We want you to help us advance women's health research!

If you are interested in this study, or possibly others that the OHSU Women's Health Research Unit is conducting, please call our confidential recruitment line at 503-494-3666 (IRB# 8297) or complete this basic health survey:


The Division of Women's Health Research
503 494-3666

The Women's Health Research Unit at OHSU: Finding New Solutions to Old Problems

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